Polynucleotides are long chains of highly purified DNA fragments. In aesthetics, they are used for their ability to stimulate tissue repair, support collagen production and improve the overall health of the skin. When injected, they act as powerful “cell messengers,” signalling the skin to repair, rebuild and restore itself.

They don’t add volume or change facial structure.
Their job is to improve the quality of the skin - firmness, elasticity, hydration, resilience and overall integrity.

Most medical-grade polynucleotides used in aesthetics are derived from highly purified salmon DNA. This is why the treatment is sometimes referred to as “salmon DNA injections.”

How it works:

• The DNA is extracted from salmon or trout milt (the reproductive cells i.e sperm).

• It undergoes extensive purification, filtration and sterilisation.

• The final solution contains no proteins, no allergens and no biological material that resembles the original tissue.

• The DNA fragments used are structurally similar to human DNA, which allows them to integrate safely into our tissues and stimulate repair.

This process produces an extremely clean, medical-grade product that has been used safely in regenerative medicine for decades before becoming popular in aesthetics.

Polynucleotides are not vegan.
Although the raw material undergoes significant purification and contains no animal tissue in the final form, the source is still salmon-derived.

We believe in transparency around this, so clients can make choices aligned with their values.

If you prefer a fully vegan alternative, head to our PRP page.
PRP uses your own blood, making it an excellent regenerative option without any animal-origin ingredients.

Polynucleotides are unique because they can be used in delicate areas that traditional injectable treatments struggle with.

Under Eyes

• crepey or thin skin

• dark circles

• textural issues

• early hollowness

• under-eye fine lines

• post-inflammatory pigmentation

Face

• early signs of ageing

• skin that looks dull, depleted or fragile

• active acne (to calm inflammation and support healing)

• acne-related texture or mild scarring

• sun-damaged skin

• general loss of elasticity

• compromised skin barrier or inflammation-prone skin

Neck

• crepey texture

• necklace lines

• weakened, thin skin

Chest

• UV damage

• fine lines

• textural roughness

Body Areas (select applications)

• knees

• elbows

• backs of hands

• areas where skin is thin, crepey, fragile or crinkled

Polynucleotides excel anywhere the skin needs strength, elasticity, support and repair rather than volume.

Polynucleotides (PNs)

• focus on repairing and strengthening the skin

• stimulate collagen, elastin and fibroblast activity

• reduce inflammation

• improve thin, fragile, crepey or sun-damaged skin

• excellent for under eyes and early ageing

• results build with each session

Skin Boosters (HA-based: Profhilo, Seventy Hyal, Restylane Vital)

• focus on hydration, glow and plumpness

• improve dryness, dullness, fine lines

• increase water content in the skin

• give fast, visible radiance

• brilliant for surface-level improvements

In short:
PNs work deeper and regenerate.
Skin boosters hydrate and brighten.

Most clients benefit from both at different stages or in different areas.

At Alien Aesthetics, polynucleotides are delivered as a structured course to ensure true skin regeneration rather than short-term surface improvement.

Treatment Course

You’ll need 3 sessions, spaced 3–4 weeks apart, for both face and under-eyes.
This gives the product time to build and stimulate collagen, elastin and tissue repair gradually.

How quickly do results show?

Polynucleotides are a slow-burn treatment.
They don’t give an instant “boost” like hyaluronic acid fillers instead, the skin strengthens and improves over several weeks as the regenerative pathways activate.

Most clients notice:

• early changes around 4–6 weeks

• clearer improvements by 8–12 weeks

• full results after completing all 3 sessions

This timeline reflects how long it takes for fibroblasts to respond and for new collagen and tissue quality to build.

Why three sessions?

Each treatment amplifies the one before it.
By the third session, clients usually see:

• smoother, stronger under-eye skin

• reduction in dark circles

• improved elasticity

• better texture

• healthier, more resilient skin overall

Maintenance

To maintain long-term results, we recommend a maintenance session every 10–12 months.
This keeps collagen production active and preserves the overall improvement in skin quality.

Polynucleotides and PRP are both regenerative treatments, but they work in very different ways and are suited to different types of clients.

Polynucleotides (Salmon DNA Regeneration)

• stronger collagen stimulation

• more predictable, consistent results

• excellent for under-eye crepiness, dark circles and fragile skin

• great for clients wanting improvement in thin or ageing skin

• ideal when targeted, precise repair is needed

• contains no proteins but is not vegan, due to salmon-derived DNA

PRP (Platelet-Rich Plasma)

• uses your own blood, fully natural and vegan-friendly

• improves texture, glow and healing

• great for clients with inflammation, acne-prone skin or sensitivity

• excellent as an “all-rounder” for skin health

• results can be more subtle and gradual

• ideal for clients seeking a completely natural skin approach

Which should you choose?

Polynucleotides are typically the better option for under-eyes, crepey skin, early ageing and fragile areas.
PRP is a great choice for clients wanting a natural, ethical, sensitive-skin-friendly option or for those focused on overall skin health and healing.

If you’re unsure, our practitioners can guide you based on your values, skin type and goals or you can explore the full details on our PRP page.

Injecting Polynucleotides (Alien Aesthetics)

This method places the product into the correct tissue layer, where it can stimulate true regeneration.
Best for clients wanting targeted, structural improvement including:

• under-eye crepiness and thinning

• dark circles caused by poor skin quality

• early hollowness

• fragile or ageing skin

• acne-related texture

• areas needing deeper repair

Why inject?

• stronger collagen and elastin stimulation

• deeper, longer-lasting results

• precise placement

• ideal for under-eyes and delicate areas

• addresses causes, not just surface appearance

Microneedling introduces the product into the superficial layers of the skin, focusing on surface-level improvement.
Perfect for clients wanting:

• brighter, fresher-looking skin

• improved texture

• reduced redness or inflammation

• healthier surface quality

• treatment without injections

• glow and refinement

Why microneedle?

• excellent for overall radiance

• improves superficial texture and tone

• supports healing

• great entry point for clients nervous about needles